Thyroid Peroxidase Antibodies and Thyroid Dysfunction in Patients with Chronic Hepatitis C Treated with Conventional Interferon and Ribavirin.

Autor: Ashraf, Amna, Mehmood, Faisal, Asghar, Asma, Bukhari, Syed Karamat Hussain Shah, Tufail, Muhammad Umair, Yousaf, Muhammad Ali
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Zdroj: Pakistan Armed Forces Medical Journal; 8/31/2022, Vol. 72 Issue 4, p1270-1270, 1p
Abstrakt: Objective: To determine the frequency of thyroid dysfunction among patients with chronic hepatitis C receiving Conventional Interferon and Ribavirin combination therapy and to compare the frequency of thyroid dysfunction among patients with thyroid peroxidase positive and negative antibodies among these patients. Study Design: Cross-sectional study. Place and Duration of Study: Gastroenterology Department of Medicine, Combined Military Hospital, Lahore Pakistan, from Jan to Jul 2017. Methodology: Patients reporting chronic hepatitis C, fulfilling the required selection criteria, and received conventional Interferon and Ribavirin therapy were included. A thyroid Function test was performed at enrollment, week-12 and week24. The outcome was measured at week 24 by the end of treatment. Anti-Thyroid Peroxidase antibody level was measured at the time of enrollment. Results: One hundred and fifty-seven patients were enrolled in the study. There was no difference in demographic data comparison. At the end of therapy, 5 (29.41%) male patients and 12 (70.59%) female patients developed TD, with the p-value of 0.019, which is statistically significant. 28 (17.83%) out of 157 patients had positive anti-TPO at baseline. The inferential analysis showed that there were significantly higher positive rates of pre-treatment anti-TPO in patients with TD (16 (94.11%) out of 17) when compared with patients with normal baseline anti-TPO (1 (5.89%) of 17), with the p-value of 0.001. Conclusion: Pre-treatment anti-Thyroid Peroxidase antibodies and female gender are the most significant risk factors for developing Thyroid Dysfunction during Interferon and Ribavirin therapy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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