| Autor: |
Mommaas, A. M., Wijsman, M. C., Verduijn, W., Vermeer, B. J., Claas, F. M. J. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Apr1991, Vol. 84 Issue 1, p170-174, 5p |
| Abstrakt: |
The nature of the interaction between γ-type endorphins and the HLA class I molecules was studied by immunoelectronmicroscopy. The ULA molecules were not involved in the actual binding of endorphin to the cell. In contrast, for the endocytosis of γ-endorphin, co-internalization of the HLA class I molecules is essential. The internalization process starts with clustering of γ-endorphin and HLA class I molecules in coated pits. Cells that do not carry HLA class I molecules (Daudi) or do not internalize HLA class I molecules (EBV-transformed B cells) bind but do not internalize γ-endorphin. On the basis of these observations, we suggest that the MHC class I molecules may function as transport molecules. Whether it is a general phenomenon that non-immunological ligands use the HLA class I molecules to get into the cell and immunological ligands viral proteins to reach the cell surface, remains to be established. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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