| Autor: |
Quinto-Ortiz, Yara Elena, González-Trujano, María Eva, Sánchez-Jaramillo, Edith, Moreno-Pérez, Gabriel Fernando, Jacinto-Gutiérrez, Salomón, Pellicer, Francisco, Fernández-Guasti, Alonso, Hernandez-Leon, Alberto |
| Předmět: |
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| Zdroj: |
Metabolites (2218-1989); Oct2022, Vol. 12 Issue 10, p916-N.PAG, 18p |
| Abstrakt: |
Fibromyalgia (FM) is a pain syndrome characterized by chronic widespread pain and CNS comorbidities. Tilia americana var. mexicana is a medicinal species used to treat anxiety, insomnia, and acute or chronic pain. However, its spectrum of analgesic efficacy for dysfunctional pain is unknown. To investigate a possible therapeutic alternative for FM-type pain, an aqueous Tilia extract (TE) and its flavonoid fraction (FF) containing rutin and isoquercitrin were evaluated alone and/or combined with clinical drugs (tramadol—TRA and pramipexol—PRA) using the reserpine-induced FM model in rats. Chromatographic analysis allowed the characterization of flavonoids, while a histological analysis confirmed their presence in the brain. TE (10–100 mg/kg, i.p.) and FF (10–300 mg/kg, i.p.) produced significant and dose-dependent antihyperalgesic and antiallodynic effects equivalent to TRA (3–10 mg/kg, i.p.) or PRA (0.01–1 mg/kg, s.c.). Nevertheless, the combination of FF + TRA or FF + PRA resulted in an antagonistic interaction by possible competitive action on the serotonin transporter or µ-opioid and D2 receptors, respectively, according to the in silico analysis. Flavonoids were identified in cerebral regions because of their self-epifluorescence. In conclusion, Tilia possesses potential properties to relieve FM-type pain. However, the consumption of this plant or flavonoids such as quercetin derivatives in combination with analgesic drugs might reduce their individual benefits. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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