| Autor: |
Keystone, E. C., Rittershaus, C., Wood, N., Snow, K. M., Flatow, J., Purvis, J. C., Poplonski, L., Kung, P. C. |
| Předmět: |
|
| Zdroj: |
Clinical & Experimental Immunology; Apr1991, Vol. 84 Issue 1, p78-82, 5p |
| Abstrakt: |
We examined the levels of TcRδ1+ T cells (total γδT cell) and δTCS1+ (γδ T cell subset) T cells in the peripheral blood (PB) and synovial fluid (SF) of 16 patients with rheumatoid arthritis (RA) and compared them to the levels in PB of patients with Felty's syndrome (FS) and 21 healthy control subjects (NML). Synovial fluid from eight patients with seronegative spondyloarthropathies (SSA) was also examined. The results demonstrated elevated levels of the δTCS1+ subset in the PB of RA and FS patients relative to NML (P < 0.05). No such differences were observed in the levels of PB TcRδ1+ T cells. The results did not appear to reflect a non-specific inflammatory response since δTCS1 T cells were elevated in the SF of RA patients relative to SSA SF and NML PB. δTCS1 T cells in SSA PB and SSA SF were comparable to NML PB. TcRδ1+ T cell levels in RA SF were higher than SSA SF levels but were comparable to those of NML PB. Taken together, the results support a pathogenic role for δTCS1+ T cells in RA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
