Alterations of Plasma Pro-Inflammatory Cytokine Levels in Children with Refractory Epilepsies.
| Autor: | Gakharia, Tatia, Bakhtadze, Sophia, Lim, Ming, Khachapuridze, Nana, Kapanadze, Nana |
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| Předmět: |
CYTOKINES
NONPARAMETRIC statistics KRUSKAL-Wallis Test STATISTICS NEURAL pathways ELECTROENCEPHALOGRAPHY CONFIDENCE intervals CHILDHOOD epilepsy DINOPROSTONE MANN Whitney U Test NEUROINFLAMMATION SEVERITY of illness index ENZYME-linked immunosorbent assay DESCRIPTIVE statistics CHEMOKINES SEIZURES (Medicine) DATA analysis software DATA analysis LONGITUDINAL method CHILDREN |
| Zdroj: | Children; Oct2022, Vol. 9 Issue 10, p1506-N.PAG, 14p |
| Abstrakt: | Paediatric epilepsy is a multifaceted neurological disorder with various aetiologies. Up to 30% of patients are considered drug-resistant. The background impact of interfering inflammatory and neuronal pathways has been closely linked to paediatric epilepsy. The characteristics of the inflamed state have been described not only in epilepsies, which are considered prototypes of an inflammatory pathophysiology, but also in patients with drug-resistant epilepsy, especially in epileptic encephalopathies. The imbalance of different cytokine levels was confirmed in several epileptic models. Chemokines are new targets for exploring neuroimmune communication in epileptogenesis, which control leukocyte migration and have a possible role in neuromodulation. Additionally, prostaglandin E2 (PGE2) is an important effector molecule for central neural inflammatory responses and may influence drug responsiveness. We measured the serum interictal quantitative levels of chemokines (CCL2, CCL4, CCL11) and PGE2 in correlation with the seizure frequency and severity in controlled and intractable childhood epilepsies. Our refractory seizure group demonstrated significantly increased concentrations of eotaxin (CCL11) compared to the controlled epilepsy group. The higher level of CCL11 was correlated with an increased seizure frequency, while the PGE2 levels were associated with the severity of seizure and epilepsy, supporting the findings that proinflammatory cytokines may contribute to epileptogenesis and possibly have a role in developing seizure resistance. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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