| Autor: |
Mafi Balani, Mohammadreza, Ghafari Novin, Mahsa, Sabbagh Alvani, Mohammadamin, Raee, Pourya, Afshar, Azar, Aghajanpour, Fakhroddin, Soltani, Reza, Hassani Moghaddam, Meysam, Fathi, Mobina, Vakili, Kimia, Salimi, Maryam, Hasani, Ahad Hasan Seyed, Abdi, Shabnam, Abdollahifar, Mohammad-Amin, Aliaghaei, Abbas |
| Předmět: |
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| Zdroj: |
Reproduction, Fertility & Development; 2022, Vol. 34 Issue 17, p1078-1088, 11p |
| Abstrakt: |
Context: Approximately 40–50% of all infertility cases are due to male infertility, and one of the most important causes of infertility is azoospermia. Aims: This study aimed to evaluate the potential effect of elderberry on the spermatogenesis process in the azoospermia mice model. Method: Thirty adult male mice were randomised into three groups: control; busulfan (45 mg/kg); and busulfan + elderberry (2%), 6 mL orally per animal. Sperm samples were collected from the tail of the epididymis, and testis specimens were also collected and then subjected to sperm parameters analysis, histopathological evaluation, reactive oxygen species (ROS), and glutathione (GSH) measurement to determine the mRNA expression and hormonal assay. Conclusions: It can be concluded that the elderberry diet may be considered a complementary treatment to improve the spermatogenesis process in busulfan-induced azoospermic mice. Implications: Considering some limitations, the elderberry diet can be an alternate option for improving testicular damage following chemotherapy. Overall, one-third of infertility cases are caused by male reproductive issues that lower the chances of fertility. There are various known causes of azoospermia related to excessive heat like cryptorchidism, varicocele, and chemotherapy agents. Therefore, the present study aimed to investigate the inaccuracy of the functional changes of testicular tissue after testicular busulfan induced azoospermia mice models. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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