| Autor: |
Yifan Li, Merbah, Mélanie, Wollen-Roberts, Suzanne, Beckman, Bradley, Mdluli, Thembi, Swafford, Isabella, Mayer, Sandra V., King, Jocelyn, Corbitt, Courtney, Currier, Jeffrey R., Liu, Heather, Esber, Allahna, Pinyakorn, Suteeraporn, Parikh, Ajay, Francisco, Leilani V., Phanuphak, Nittaya, Maswai, Jonah, Owuoth, John, Kibuuka, Hannah, Iroezindu, Michael |
| Zdroj: |
Emerging Infectious Diseases; Nov2022, Vol. 28 Issue 11, p2214-2225, 12p, 8 Graphs |
| Abstrakt: |
Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya, Nigeria, Tanzania, and Uganda) and in Thailand, including persons living with HIV-1. We detected IgG responses to SARS-CoV-2 spike (S) subunit 2 protein in 1.8% of participants. Profiling against 23 coronavirus antigens revealed that responses to S, subunit 2, or subunit 1 proteins were significantly more frequent than responses to the receptor-binding domain, S-Trimer, or nucleocapsid proteins (p<0.0001). We observed similar responses in persons with or without HIV-1. Among all coronavirus antigens tested, SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome coronavirus antibody responses were much higher in participants from Africa than in participants from Thailand (p<0.01). We noted less pronounced differences for endemic coronaviruses. Serosurveys could affect vaccine and monoclonal antibody distribution across global populations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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