| Autor: |
Al-Zayadi, Fouad Qasim Jubair, Kareem, Ahmed Shayaa, Shakir, Ali S., Alshibly, Ifad Kerim, Mahmood, Ammad Hasan, Jabbar, Abdullah Hasan |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 10/25/2022, Vol. 2398 Issue 1, p1-6, 6p |
| Abstrakt: |
Urological tumors considered as one of the most common heterogeneous class of malignancies in the world, comprise bladder, prostate, kidney, and testis tumors, are the most common neoplasms of the genitourinary tract (GUT). This study aims to investigate the serum levels of Fas and FasL in urologic tumor patients and healthy subjects. This case-control study involved a total of (80) subjects; include (50) patients with urological tumors consist of (35) males and (15) females; and (30) healthy donors (HD) as control group consist of (20) male and (10) female. Their ages ranged from (9-88) years. Case information for each patient were taken from the report of the diagnosis which were: name, sex, age, biopsy site. The patients visited urological surgery unit in Hilla Teaching Hospital during the period (December 2018 to October 2019). After patient admission to the urological surgery unit, 3mL of blood were collected from each patient for serological evaluations. The serological markers (sFas & sFasL) were evaluated through sandwich-ELISA technique. The results showed that mean of sFas concentrations in patients of the urological tumors and control group was 3304 pg/mL ±404.7 and 2767.5 pg/mL ±720 respectively. Statistically, there is a significant difference (P value ˂ 0.05) between them. Likewise, mean of sFasL concentrations in urologic tumor patients and control group was 425.5 pg/mL ±181 and 305.5 pg/mL ±106 respectively, and there is a highly significant difference (P value ˂ 0.001) between them. It was concluded that serum levels of both sFas and sFasL are increased in urological tumor patients. These markers can be used as an indicator to the urological tumors through further studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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