| Autor: |
Muhammed, Omar, Al-Rubae'i, Salwa |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 10/25/2022, Vol. 2398 Issue 1, p1-10, 10p |
| Abstrakt: |
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease resulting from an interaction of environmental and genetic factors. Deficiency of 25-hydroxycholecalciferol [25(OH)D3] appears to be an environmental and genetic risk factor involved in susceptibility to MS. The aims of the current study were to verify the link of single nucleotide polymorphisms (SNPs) in CYP27A1 and CYP27B1genes, 25(OH)D3 status, and relapsing-remitting MS (RRMS) risk. Genotyping of CYP27A1 and CYP27B1 SNPs and serum 25(OH)D3 levels were investigated both in 97 RRMS patients (group I) and in 35 control group (group II). Genetic analysis was performed by tetra-primer ARMS-PCR, and serum levels of 25(OH)D3 were measured by a double-antibody sandwich Enzyme-Linked Immunosorbent Assay (ELISA) kit. The distribution of genotypes and alleles frequencies (CC, TT) was not significantly different between RRMS patients and controls, while TC genotype for rs703842 of CYP27B1 gene showed a significant higher frequency in RRMS patients compared with control group. Our data concluded that TC genotype for rs703842 of CYP27B1 gene found to be risk factor for MS disease in Iraqi population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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