| Autor: |
Faraj, Fadhil Lafta, Salman, Salih Mahdi, Ali, Tammar Hussein |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 10/25/2022, Vol. 2398 Issue 1, p1-8, 8p |
| Abstrakt: |
Series of new compounds have been synthesized via coupling of heterocyclic compound with different halides alkyl chain length (C10-C18). The precursor of synthesis got from phenyl hydrzinhydrochloride in three steps. The first is the reaction with isoproylmethyl ketone in acetic acid to yield (2, 3, 3-trimethyl-3H-indole) using Fischer reaction. The second is treatment of the later with POCl3 in.DMF through Vilsmeier-Haack reaction to produce 2-3, 3-dimethyl-1, 3-dihydro-indol-2-ylidene)-malonaldehyde. Finally, the reaction with 2-aminophenol in glacial acetic acid to produce the precursor (2-(3,3-dimethylindolin-2-ylidene)-3-(2-hydroxyphenylimino) propanal. Five ether derivatives build from this compound by Williamson reaction using (C10-C18) alkyl halides in present of potassium carbonate. The structure and purity of the synthesized compound was confirmed by spectroscopy methods including IR techniques, both 1H, 13C NMR spectroscopy in addition to CHN analysis. The biological activity and surface tension properties of those compounds were investigated and most of them show compatibility with the aim of the synthesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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