Effectiveness of Autologous Fat Transfer in the Treatment of Scar-Related Conditions: A Systematic Review and Meta-analysis.

Autor: Al Qurashi, Abdullah A., Siddiqi, Ahmed Kamal, Alghamdi, Abdulrahman Abdulaziz, Aljalfan, Abdullah Ali N., Almenhali, Ahmed Abdullah, Al Jabr, Faisal Ali, Rashid, Ahmed Mustafa, Almas, Talal, Menezes, Ritesh G.
Zdroj: Aesthetic Plastic Surgery; Oct2022, Vol. 46 Issue 5, p2564-2572, 9p
Abstrakt: Background and Aim: Autologous fat transfer (AFT) has been introduced as a potential treatment option for scar-tissue and its related symptoms. However, the scientific evidence for its effectiveness remains unclear. This meta-analysis aims to evaluate the available evidence regarding the effectiveness of autologous fat transfer for the treatment of scar-tissue and its related conditions. Methods: PubMed/Medline database was queried from its inception till the end of November 2021. All the relevant studies assessing the effect of autologous fat transfer in the treatment of scar-related conditions were pooled in using a random-effects model. Results: 9 studies (n=179) were included in the meta-analysis. Pooled analysis demonstrates significant improvement in all subscales of the POSAS patient score with most prominent in color 2.4 points (95% CI 1.78–3.041), stiffness 2.9 points (95% CI 2.33–3.45), irregularity 2.2 points (95% CI 1.093–3.297) and thickness 1.8 points (95% CI 0.804–2.719), respectively. Pain and itch improved relatively lesser, 1.3 points (95% CI 0.958–1.674) and 0.6 points (95% CI 0.169–1.215), respectively. The POSAS observer scale showed a relatively lower improvement with the least in vascularity 0.5 points (95% CI 0.098–0.96), pigmentation 0.8 points (95% CI 0.391–1.276) and surface area 0.8 points (95% CI 0.34–1.25). Thickness improved by 1.4 points (95% CI 0.582–2.3), relief 1.0 points (95% CI 0.461–1.545) and pliability 1.5 points (95% CI 1.039–2.036). Conclusion: Our findings demonstrate that autologous fat transfer (AFT) is a promising treatment for scar-related conditions as it provides beneficial results in the scar quality. Future research should focus on the long-term effects of AFT and high-level evidence studies such as, randomized controlled trials (RCTs) and cohort studies are required. Level of Evidence III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: