| Autor: |
Stoye, David Q., Boardman, James P., Osmond, Clive, Sullivan, Gemma, Lamb, Gillian, Black, Gill S., Homer, Natalie Z. M., Nelson, Nina, Theodorsson, Elvar, Reynolds, Rebecca M., Mörelius, Evalotte, Homer, Natalie Zm |
| Předmět: |
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| Zdroj: |
Archives of Disease in Childhood -- Fetal & Neonatal Edition; Sep2022, Vol. 107 Issue 5, pF565-F567, 3p |
| Abstrakt: |
Background: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy.Methods: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models.Results: Compared with infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, 95% CI: -14.1 to 20.4), had a flattened diurnal slope across infancy.Conclusions: Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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