| Autor: |
de Oliveira, Diego Pinto, Garcia, Eliana de Faria, de Oliveira, Mariana Assíria, Candido, Luiza C. M., Coelho, Fernanda M., Costa, Vivian Vasconcelos, Batista, Nathália Vieira, Queiroz-Junior, Celso Martins, Brito, Larissa Froede, Sousa, Lirlândia Pires, Souza, Daniele G., Amaral, Flávio Almeida, de Pádua, Rodrigo Maia, Teixeira, Mauro Martins, Braga, Fernão Castro |
| Předmět: |
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| Zdroj: |
Planta Medica; Oct2022, Vol. 88 Issue 13, p1123-1131, 9p |
| Abstrakt: |
cis -Aconitic acid is a constituent from the leaves of Echinodorus grandiflorus , a medicinal plant traditionally used in Brazil to treat inflammatory conditions, including arthritic diseases. The present study aimed to investigate the anti-arthritic effect of cis -aconitic acid in murine models of antigen-induced arthritis and monosodium urate-induced gout. The possible underlying mechanisms of action was evaluated in THP-1 macrophages. Oral treatment with cis -aconitic acid (10, 30, and 90 mg/kg) reduced leukocyte accumulation in the joint cavity and C-X-C motif chemokine ligand 1 and IL-1 β levels in periarticular tissue. cis -Aconitic acid treatment reduced joint inflammation in tissue sections of antigen-induced arthritis mice and these effects were associated with decreased mechanical hypernociception. Administration of cis -aconitic acid (30 mg/kg p. o.) also reduced leukocyte accumulation in the joint cavity after the injection of monosodium urate crystals. cis -Aconitic acid reduced in vitro the release of TNF- α and phosphorylation of I κ B α in lipopolysaccharide-stimulated THP-1 macrophages, suggesting that inhibition of nuclear factor kappa B activation was an underlying mechanism of cis -aconitic acid-induced anti-inflammatory effects. In conclusion, cis -aconitic acid has significant anti-inflammatory effects in antigen-induced arthritis and monosodium urate-induced arthritis in mice, suggesting its potential for the treatment of inflammatory diseases of the joint in humans. Additionally, our findings suggest that this compound may contribute to the anti-inflammatory effect previously reported for E. grandiflorus extracts. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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