| Autor: |
Bratova, Monika, Brat, Kristian, Hurdalkova, Karolina, Barinova, Magda, Drosslerova, Marie, Kultan, Juraj, Wanke, Matyas, Koubkova, Leona, Krejci, Jana, Svaton, Martin |
| Předmět: |
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| Zdroj: |
Journal of Adolescent & Young Adult Oncology; Oct2022, Vol. 11 Issue 5, p451-458, 8p |
| Abstrakt: |
Purpose: Aim was to analyze demographic and tumor characteristics, treatment, and survival of patients with lung cancer younger than 40 years of age (U40) compared to older subgroups (41–70 and >70 years). Methods: We analyzed data of young patients diagnosed and treated in 2011–2019 in five pneumo-oncology centers in Czechia. Standard descriptive statistics, chi-squared test, Fisher exact test, and Kaplan-Meier survival analysis were used. p-Values <0.05 were considered significant. These data were compared with two control subgroups (cohort 1: 41–70 years, cohort 2: >70 years). Results: We identified 66 patients U40, 61 with non-small cell lung cancer (NSCLC)—50.8% men, mean age 34.6 years, 54.1% nonsmokers, daily good performance status, and 82% in stage IV. Adenocarcinomas dominated, endothelial growth factor receptor (EGFR) positivity was less common than in older groups contrary to anaplastic lymphoma kinase (ALK) mutations. Median progression-free survival was 3.7 months (vs. 4.9 and 6.2 months; p = 0.006) and overall survival reached 11.7 months (vs. 22.3 and 27.3 months; p < 0.001). Young patients in stage IV and never-smokers had shorter survival than older patients. Conclusion: Patients with NSCLC U40 had significantly worse prognosis than older patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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