| Autor: |
Freitas Queiroz, Maria Alice, Moura das Neves, Pablo Fabiano, Souza Lima, Sandra, da Costa Lopes, Jeferson, da Silva Torres, Maria Karoliny, Vieira Cayres Vallinoto, Izaura Maria, Araújo Bichara, Carlos David, Ferreira dos Santos, Erika, Figueiredo Magalhães de Brito, Mioni Thieli, Soares da Silva, Andréa Luciana, de Meira Leite, Mauro, Póvoa da Costa, Flávia, do Socorro de Almeida Viana, Maria de Nazaré, Barbosa Rodrigues, Fabíola Brasil, Lima de Sarges, Kevin Matheus, Damasceno Cantanhede, Marcos Henrique, da Silva, Rosilene, Carneiro Bichara, Clea Nazaré, Soares van den Berg, Ana Virgínia, Lameira Veríssimo, Adriana de Oliveira |
| Předmět: |
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| Zdroj: |
Frontiers in Cellular & Infection Microbiology; 6/30/2022, Vol. 12, p1-11, 11p |
| Abstrakt: |
The duration and severity of COVID-19 are related to age, comorbidities, and cytokine synthesis. This study evaluated the impact of these factors on patients with clinical presentations of COVID-19 in a Brazilian cohort. A total of 317 patients diagnosed with COVID-19 were included; cases were distributed according to clinical status as severe (n=91), moderate (n=56) and mild (n=170). Of these patients, 92 had acute COVID-19 at sample collection, 90 had already recovered from COVID-19 without sequelae, and 135 had sequelae (long COVID syndrome). In the acute COVID-19 group, patients with the severe form had higher IL-6 levels (p=0.0260). In the post-COVID-19 group, there was no significant difference in cytokine levels between groups with different clinical conditions. In the acute COVID-19 group, younger patients had higher levels of TNF-a, and patients without comorbidities had higher levels of TNF-a, IL-4 and IL-2 (p<0.05). In contrast, patients over age 60 with comorbidities had higher levels of IL-6. In the post-COVID-19 group, subjects with long COVID-19 had higher levels of IL-17 and IL-2 (p<0.05), and subjects without sequelae had higher levels of IL-10, IL-6 and IL-4 (p<0.05). Our results suggest that advanced age, comorbidities and elevated serum IL-6 levels are associated with severe COVID-19 and are good markers to differentiate severe from mild cases. Furthermore, high serum levels of IL-17 and IL-2 and low levels of IL-4 and IL-10 appear to constitute a cytokine profile of long COVID-19, and these markers are potential targets for COVID-19 treatment and prevention strategies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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