| Autor: |
Gordienko, A. I., Beloglazov, V. A., Anikhovskaya, I. A., Markelova, M. M., Khimich, N. V., Yakovlev, M. Yu. |
| Předmět: |
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| Zdroj: |
Human Physiology; Oct2022, Vol. 48 Issue 5, p577-581, 5p |
| Abstrakt: |
Clinical and laboratory examination was performed for 50 patients with ankylosing spondylitis (AS) (mean age 38.1 ± 1.3 years) with degree II of general activity of the pathological process and disease history of 1–8 years (mean BASDAI score 3.6 ± 0.2). Close relationships between the level of oxidative stress, the severity of low-intensity inflammation, and the activity of the humoral component of anti-endotoxin immunity were observed in the active phase of AS, implicating endotoxin aggression of intestinal origin in disease pathogenesis. Based on cluster analysis, a deficiency of class M anti-endotoxin antibodies was associated with a higher level of oxidative stress and low-intensity inflammation in the AS patients. Medical procedures and drugs that can normalize systemic endotoxemia were therefore considered advisable to include in AS treatment. The anti-endotoxin component of the treatment is expected to increase the treatment efficacy and to reduce the need for cytostatics and, therefore, their iatrogenic side effects. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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