| Autor: |
Suwannaying, Kunanya, Techavichit, Piti, Komvilaisak, Patcharee, Laoaroon, Napat, Narkbunnam, Nattee, Sanpakit, Kleebsabai, Chiengthong, Kanhatai, Chotsampancharoen, Thirachit, Sathitsamitphong, Lalita, Chalongpon Santong, Seksarn, Panya, Hongeng, Suradej, Wiangnon, Surapon |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Pediatrics; Sep2022, Vol. 65 Issue 9, p453-458, 6p |
| Abstrakt: |
Background: In 2013, the Thai Pediatric Oncology Group (ThaiPOG) introduced a national protocol in which highdose chemotherapy plus stem cell rescue is performed without immunotherapy. Methods: This study aimed to elucidate the outcomes of high-risk neuroblastoma (HR-NB) patients treated with the ThaiPOG protocol. This retrospective cohort review included 48 patients (30 males, 18 females) with a median age of 3 years (range, 8 months to 18 years) who were treated at 5 ThaiPOG treatment centers in Thailand in 2000-2018. Results: Eight of the 48 patients showed MYCN amplification. Twenty-three patients (48%) received 131I-meta-iodobenzylguanidine prior to high-dose chemotherapy and stem cell rescue. The majority of patients achieved a complete or very good response prior to consolidation treatment. The 5-year overall survival (OS) and event-free survival (EFS) rates were 45.1% and 40.4%, respectively. Patients aged >2 years had a nonsignificantly higher mortality risk (hazard ratio [HR], 2.66; 95% confidence interval [CI], 0.92-7.68; P=0.07). The MYCN amplification group had lower OS and EFS rates than the MYCN nonamplification group, but the difference was not statistically significant (45% OS and 37.5% EFS vs. 33.3% OS and 16.6% EFS; P=0.67 and P=0.67, respectively). Cisretinoic acid treatment for 12 months was a strong prognostic factor that could reduce mortality rates among HR-NB patients (HR, 0.27; 95% CI, 0.09-0.785; P=0.01). Conclusion: High-dose chemotherapy plus stem cell rescue followed by cis-retinoic acid for 12 months was well tolerated and could improve the survival rates of patients with HR-NB. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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