| Autor: |
Hyodo, S., kishi, T., Kittaka, E., Suzawa, T., Tanabe, A., Tanaka, Y., Sakano, T., Usui, T. |
| Předmět: |
|
| Zdroj: |
Clinical & Experimental Immunology; Jul1983, Vol. 53 Issue 1, p140-144, 5p |
| Abstrakt: |
The induction of autorosette forming cells (ARFC) with phytohaemagglutinin (PHA) in human peripheral blood lymphocytes (PBL) was examined. After 24 h of incubation with PHA, the level of ARFC in PBL was markedly increased but subsequently decreased to about one-third of the peak level at 96h of culture. When PBL were pre-treated with actinomycin D, or cultured with puromycin, the induction of ARFC was completely blocked. Pre-treatment of PBL with mitomycin C (MMC) had no effect on induction of ARFC, wheareas DNA synthesis was completely blocked. These data indicate that the generation of autologous red blood cells receptors is a relatively early event in PHA activated PBL, and that it is independent of DNA synthesis but dependent on RNA and protein synthesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
