| Autor: |
Kotb Elmala, Moustafa, Suliman, Hany Abdelaziz, Al-shokary, Ashraf Hamed, Ibrahim, Asmaa Obada, Kamal, Naglaa M., Elshorbagy, Hatem Hamed, Nasef, Khaled Amin, El Din Fathallah, Mohamed Gamal |
| Předmět: |
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| Zdroj: |
Journal of Child Neurology; Oct2022, Vol. 37 Issue 10/11, p833-839, 7p |
| Abstrakt: |
Background: There is still a need for more studies to evaluate the role of vitamin D3 in pediatric migraine prophylaxis. Objectives: We aimed to evaluate the effects and safety of vitamin D3 supplementation to topiramate on pediatric migraine. Methods: A double-blinded prospective clinical trial was conducted on 5- to 14-year-old children with migraine. They were randomly assigned in a 1:1 ratio into 2 groups, one with vitamin D3 supplementation (the supplementation group) and the other without vitamin D supplementation (the placebo group). The supplementation group received topiramate plus one 5000-IU dose of vitamin D3 daily for 4 months. The placebo group received topiramate with a placebo capsule without any effective substances. The primary outcomes were a monthly frequency of headache attacks, a good response to intervention, and reduction in migraine severity, duration, and disability before and after treatment. Fifty-six children completed the trial. Vitamin D3 supplementation to topiramate was more effective than the placebo group in the reduction of monthly frequency (6231.31 vs 9792.24 times, P =.01) and disability score for migraines (17 566.43 vs 25 187.65, P =.04). A good response was observed in 76.13% of patients in the vitamin D3 supplementation group and 53.5% of patients in the placebo group, and vitamin D3 supplementation was significantly more effective than placebo (P =.01). Side effects were observed in 13.3% and 20% of the intervention group and placebo groups, respectively, P =.5. Conclusion: Vitamin D3 supplementation in pediatric migraine prophylaxis could be a well-tolerated, safe, and effective strategy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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