Cardiac 123I-mIBG scintigraphy for prediction of catheter ablation outcome in patients with atrial fibrillation.

Autor: Sazonova, S. I., Varlamova, J. V., Nikitin, N. A., Minin, S. M., Kisteneva, I. V., Batalov, R. E., Mishkina, A. I., Ilushenkova, Y. N., Zavadovsky, K. V., Popov, S. V., Romanov, A. B.
Zdroj: Journal of Nuclear Cardiology; Oct2022, Vol. 29 Issue 5, p2220-2231, 12p
Abstrakt: Background: Previous studies show inconsistent results on the role of innervation imaging (with 123I-mIBG) in predicting late atrial fibrillation (AF) recurrence after catheter ablation (CA). These studies included patients with paroxysmal AF and studied prognostic value of post-CA I-123-mIBG parameters. Current study investigated the ability of pre CA 123-I-mIBG imaging to predict late AF recurrence in patients with persistent AF. Methods: 123I-mIBG cardiac imaging was performed before CA in 82 patients with persistent AF. Patient was followed for 12 months. Results: Multivariable analysis demonstrated that late heart-to-mediastinum ratio (H/Mlate) and washout rate (WR) were independent predictors of AF recurrence. ROC-curve analysis data showed that H/Mlate <1.6 (sensitivity 73.53%, specificity 81.3%, AUC 0.792, P <.001) and WR > 25.11 (sensitivity 70.6%, specificity 70.8.3%, AUC 0.712, P <.001) indicate high probability of AF relapses during 12 months after CA. Conclusion: Pre-CA parameters of global cardiac sympathetic activity estimated by 123I-mIBG scintigraphy are associated with late AF relapses in persistent AF patients with normal LVEF and absence of significant CAD. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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