| Abstrakt: |
Introduction: Obstructive Sleep Apnea (OSA) Syndrome is highly prevalent in Down syndrome (DS) children, due to their specific craniofacial position (hypoplasia of the maxilla), besides obesity and relative macroglossia. No screening questionnaire has been validated for Down syndrome children. Objectives: The study aims to compare the scores of the OSA-18 questionnaire of Down syndrome children and normal children. Methods: For this case-control study, we invited 42 children, 21 with Down syndrome and 21 as the control group (CG). All children realized full-night polysomnography and their parents answered the OSA-18 questionnaire. Children of both groups were matched for age, gender, BMI, and obstructive sleep apnea severity with similar AHI. Results: All children were diagnosed with obstructive sleep apnea, 8 of each group being diagnosed mild, 4 moderate, and 9 severe. OSA-18 scores were similar in both groups (DS=60.14 and CG=62.14), for mild Obstructive Sleep Apnea the score was 59 in Down syndrome vs 58,25 in control group, for moderate obstructive sleep apnea 53 in Down syndrome vs 70 in control group, and for severe Obstructive Sleep Apnea 64.1 vs 61 in control group. Accuracy for the screening of moderate to severe was similar in Down syndrome children and control group children. Conclusions: In our study population, the screening questionnaire OSA-18 can be used in Down syndrome children for the suspicion of Obstructive Sleep Apnea with similar accuracy as in nonsyndromic children, however, larger populations have to be enrolled. [ABSTRACT FROM AUTHOR] |
