| Autor: |
Garcia Martins, Regina Helena, Battistel Santana, Renato, Gonçalves Pierri, Isabella, Santos Carneiro, Neemias, Palaro Braga, Alexandre, Loli, Alessandra, Benito Pessin, Adriana Bueno |
| Předmět: |
|
| Zdroj: |
International Archives of Otorhinolaryngology; 2022 Supplement, Vol. 26, p3-3, 1/4p |
| Abstrakt: |
Introduction: During aging, the larynx undergoes structural and functional changes, called presbyphonia, which can compromise the vibratory pattern of the vocal folds. Among the various structural alterations, the increase in the extracellular fibrous matrix and the decrease in hyaluronic acid stand out. As fibroblasts are important components of the lamina propria of the vocal folds, responsible for the production of collagen and elastic fibers, we consider it important to know the behavior of these cells in the larynx of the elderly in order to better understand the pathophysiology of presbyphonia. Objective: To study the concentration of fibroblasts in the vocal folds of the elderly. Methods: The vocal folds of 13 cadavers were divided into two groups (n-5, 18-40 years; n-8, above or equal to 75 years), dissected and prepared for immunohistochemical analysis using the FSP-1 antibody to fibroblasts. Sites analyzed: macula flavas and medial portion of the vocal folds. The AVC softwas used to count the cells. Results: A higher concentration of fibroblasts was identified in the macula flava of the larynx of young and in the medial portion of the vocal folds of the elderly, without. statistically significant differences. So, there was no effect of age on the concentration of fibroblasts in the vocal folds. Conclusion: In the larynx of the elderly, the fibroblast population remains similar to the young adults, both in the macula flava and in the body of the vocal folds. Functional changes in these cells are probably more marked than quantitative ones. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
