| Autor: |
Haas, Quentin, Markov, Nikita, Muerner, Lukas, Rubino, Viviana, Benjak, Andrej, Haubitz, Monika, Baerlocher, Gabriela M., Ng, Charlotte K. Y., Münz, Christian, Riether, Carsten, Ochsenbein, Adrian F., Simon, Hans-Uwe, von Gunten, Stephan |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology; 9/23/2022, Vol. 13, p1-14, 14p |
| Abstrakt: |
While inhibitory Siglec receptors are known to regulate myeloid cells, less is known about their expression and function in lymphocytes subsets. Here we identified Siglec-7 as a glyco-immune checkpoint expressed on nonexhausted effector memory CD8+ T cells that exhibit high functional and metabolic capacities. Seahorse analysis revealed higher basal respiration and glycolysis levels of Siglec-7+ CD8+ T cells in steady state, and particularly upon activation. Siglec-7 polarization into the T cell immune synapse was dependent on sialoglycan interactions in trans and prevented actin polarization and effective T cell responses. Siglec-7 ligands were found to be expressed on both leukemic stem cells and acute myeloid leukemia (AML) cells suggesting the occurrence of glyco-immune checkpoints for Siglec-7+ CD8+ T cells, which were found in patients' peripheral blood and bone marrow. Our findings project Siglec-7 as a glyco-immune checkpoint and therapeutic target for T cell-driven disorders and cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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