| Autor: |
Croft, Susan, Adams, D. D., Purves, H. D. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jun1975, Vol. 20 Issue 3, p549-553, 5p |
| Abstrakt: |
NZB, NZB × NZW and random-bred mice were exposed to continuous low-dosage gamma irradiation, 20 R/yr, about 200 times normal background irradiation, throughout their adult lives. The aim was to test for the possibility that their autoimmune disorders are based on a defective DNA repair mechanism which permits development of forbidden clones of immunocytes through abnormal somatic mutation. The irradiation had no effect on NZB × NZW mice, which died predominantly of renal failure, as usual, with a mean life span of 374 days. Roth the NZB and the random-bred mice died significantly sooner than control, unirradiated animals. The reason for this is not clear. There was no increase in tumour formation. The NZB mice died in two clusters, several months apart. It is concluded that any effect of the irradiation was insufficient to support the idea that defective DNA repair is the genetically determined defect causing autoimmunity in these mice. The possibility that the irradiation increased the rate of formation of harmful forbidden clones by somatic mutation in the NZB mice cannot be excluded. Alternatively, the shorter life-span of the irradiated animals may have been due to slight impairment of immune defence against micro-organisms or increased rate of ageing processes in the irradiated mice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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