THE IMMUNOLOGICAL RESPONSIVENESS OF GERM--FREE MICE THYMECTOMIZED AT BIRTH J. ANTIBODY PRODUCTION AND SKIN HOMOGRAFT REJECTION.

Autor: Miller, J. F. A. P., Dukor, P., Grant, Gwendoline, Sinclair, N. R. St C., Sacquet, E.
Předmět:
Zdroj: Clinical & Experimental Immunology; Jul1967, Vol. 2 Issue 4, p531-542, 12p
Abstrakt: The article cites that a primary consequence of thymectomy is some degree of immunological impairment was generally not as extreme as it was in thymectomized conventional mice. Mice thymectomized at birth generally exhibit an impairment of the capacity to react to sheep erythrocytes and to reject skin homografts. When such mice are raised in the conventional state, they develop a wasting disease. Thymectomy was performed on germ-free mice and conventional mice of the same strain within the first 24 hr after birth by the method used routinely. Anaesthesia was induced by refrigerating the babies in a sterile glass tube continuous with the isolator and packed on its external surface with ice.
Databáze: Complementary Index