| Autor: |
Nkolola, Joseph P., Yu, Jingyou, Wan, Huahua, Chang, Aiquan, McMahan, Katherine, Anioke, Tochi, Jacob-Dolan, Catherine, Powers, Olivia, Ye, Tianyi, Chandrashekar, Abishek, Sellers, Daniel, Barrett, Julia, Loo, Yueh-Ming, Esser, Mark T., Carnahan, Robert H., Crowe Jr., James E., Barouch, Dan H. |
| Předmět: |
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| Zdroj: |
Science Translational Medicine; 10/5/2022, Vol. 14 Issue 665, p1-7, 7p |
| Abstrakt: |
Human monoclonal antibodies (mAbs) that target the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) offer a promising approach for the prevention and treatment of coronavirus disease 2019 (COVID-19). Given suboptimal global vaccination rates, waning immunity in vaccinated individuals, and the emergence of SARS-CoV-2 variants of concern, the use of mAbs for COVID-19 prevention may increase and may need to be administered together with vaccines in certain settings. However, it is unknown whether administration of mAbs will affect the immunogenicity of SARS-CoV-2 vaccines. Using an adenovirus vector–based SARS-CoV-2 vaccine, we show that simultaneous administration of the vaccine with SARS-CoV-2 mAbs does not diminish vaccine-induced humoral or cellular immunity in cynomolgus macaques. These results suggest that SARS-CoV-2 mAbs and viral vector-based SARS-CoV-2 vaccines can be administered together without loss of potency of either product. Additional studies will be required to evaluate coadministration of mAbs with other vaccine platforms. Combinations for COVID-19: Vaccines and monoclonal antibody (mAb) therapeutics are now mainstays for combating the COVID-19 pandemic. However, it is not clear whether administering vaccines and mAbs at the same time or one shortly after the other affects the efficacy of the vaccine. Here, Nkolola and colleagues simultaneously administered an adenovirus-based SARS-CoV-2 vaccine and a SARS-CoV-2–specific mAb cocktail to nonhuman primates. They found that simultaneous administration of the mAb cocktail with the vaccine did not impair vaccine-induced humoral or cellular immunity in the animals, suggesting that administration of these treatments at the same time would not impair vaccine efficacy in humans. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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