| Autor: |
Singh, Ashutosh, Jha, Anshu Kumar, Kalita, Bipul Chandra, Jha, Dharmendra Kumar, Alok, Yash |
| Zdroj: |
International Journal of Diabetes in Developing Countries; Jul2022, Vol. 42 Issue 3, p523-528, 6p |
| Abstrakt: |
Background: Inflammation plays a central role in pathogenesis of diabetic nephropathy (DN), a major cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). Neutrophil lymphocyte ratio (NLR) is a novel and easily available inflammatory marker that can be used to predict DN. Objective: The objective was to evaluate NLR as a predictive and prognostic marker for DN. Material and methods: It was an observational cross-sectional study. A total of 324 T2DM patients and 212 healthy controls (HC) were selected by consecutive sampling between June 2019 and June 2020. Complete blood count, erythrocyte sedimentation rate (ESR), renal function parameters, 24-h urinary protein, and fundoscopy were done. Appropriate statistical analysis was applied using SPSS software. Results: Of 324 T2DM patients, 146 (45%) had DN and 178 (55%) did not. Mean NLR (± SD) for T2DM without DN, T2DM, with DN and HC was 2.73 ± 0.91, 4.85 ± 1.37, and 2.05 ± 0.73, respectively (p-value < 0.05). Positive correlation between NLR vs ESR (r = + 0.335), creatinine (r = + 0.282), and 24-h urinary protein (r = + 0.508) (p-value < 0.001) and negative correlation with hemoglobin (r = − 0.335) and estimated glomerular filtration rate (r = − 0.163) (p-value = 0.001) was observed. Receiver operating characteristic curve for NLR was highest (0.882) (Std. error − 0.019 and p-value < 0.000), and best cut-off value was 3.28 (sensitivity = 89.7% and specificity = 69.7%). Conclusion: NLR is a better and reliable inflammatory marker compared to a frequently assayed inflammatory parameter like ESR. Thus, it can be considered as a predictive and prognostic marker for DN. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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