| Autor: |
Leclercq, Elise, Moncomble, Aurélien, Debavelaere, Céline, Beaucamp, Mathieu, Penhoat, Maël, Chausset-Boissarie, Laëtitia |
| Předmět: |
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| Zdroj: |
Green Chemistry; 10/7/2022, Vol. 24 Issue 19, p7388-7394, 7p |
| Abstrakt: |
Herein, we report direct C3 trifluoromethylation of 2-pyridones including unprotected derivatives by an electrochemical approach using the readily available Langlois reagent as the CF3 source in the absence of electrolytes. The trifluoromethylation under transition metal- and oxidant-free conditions occurred site-selectively to give the desired products in moderate to good yields under ambient conditions. Interestingly, significant acceleration rates, improved yields and selectivities as well as reduced energy consumption were achieved under microfluidic conditions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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