| Autor: |
Racheleesky, G. S., McConnachie, P. R., Ammann, A. J., Terasaki, P. I., Stiehm, E. R. |
| Předmět: |
|
| Zdroj: |
Clinical & Experimental Immunology; Jan1975, Vol. 19 Issue 1, p1-9, 9p |
| Abstrakt: |
Antibody-dependent cell immunity to the lymphocyte system (ABCIL) has been shown lo be a function of a non-t hymns-processed cell in the experimental animal. To evaluate its role in the human and lo assess its clinical usefulness, we assessed ABCIL in twenty-live patients with various immunodeficiency (ID) syndromes. Our technique measures the lysis of 51Cr-labelled normal human lymphocytes coated with HLA-specific antibody. Cytotoxicity is expressed as a percentage of 51Cr released after subtracting the spontaneous target cell release. Mean values in normals are 20±2 (s.e.). The ten patients with AB deficiency had a mean ABCIL of 7.9±2 (P<0.01). All eight patients with cellular ID had normal ABCIL (18±2), while the ten patients with combined ID had variable results. Effector cell function in the ABCIL test correlated (r = 0.74; P<0.05) with the percentage of B cells in the peripheral blood. No correlation was found between ABCIL function and serum immunoglobulin levels or rosette-forming cells in the peripheral blood. There is a function for B lymphocytes other than as a precursor of antibody-synthesizing cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
