Potential of olive oil and its phenolic compounds as therapeutic intervention against colorectal cancer: a comprehensive review.
| Autor: | Sain, Arindam, Sahu, Sakshi, Naskar, Debdut |
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| Předmět: |
THERAPEUTIC use of olive oil
THERAPEUTIC use of antineoplastic agents MEDITERRANEAN diet OLIVE oil PHENOLS NEOVASCULARIZATION inhibitors NEOVASCULARIZATION APOPTOSIS COLORECTAL cancer TREATMENT effectiveness MOLECULAR biology CELLULAR signal transduction DIETARY supplements CELL lines MEDICAL research |
| Zdroj: | British Journal of Nutrition; 10/14/2022, Vol. 128 Issue 7, p1257-1273, 17p |
| Abstrakt: | Colorectal cancer (CRC) is one of the major causes of death across the world and incidence rate of CRC increasing alarmingly each passing year. Diet, genomic anomalies, inflammation and deregulated signalling pathways are among the major causes of CRC. Because of numerous side effects of CRC therapies available now, researchers all over the world looking for alternative treatment/preventive strategy with lesser/no side effects. Olive oil which is part of Mediterranean diet contains numerous phenolic compounds that fight against free radicals and inflammation and also well-known for protective role against CRC. The current review focused on the recent evidences where olive oil and its phenolic compounds such as hydroxytyrosol, oleuropein and oleocanthal showed activities against CRC as well to analyse the cellular and molecular signalling mechanism through which these compounds act on. These compounds shown to combat CRC by reducing proliferation, migration, invasion and angiogenesis through regulation of numerous signalling pathways including MAPK pathway, PI3K-Akt pathway and Wnt/β-catenin pathway and at the same time, induce apoptosis in different CRC model. However, further research is an absolute necessity to establish these compounds as nutritional supplements and develop therapeutic strategy in CRC. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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