| Autor: |
Ma, Guanqin, Zhang, Deng-Feng, Zou, Qing-Cui, Xie, Xiaochun, Xu, Ling, Feng, Xiao-Li, Li, Xiaohong, Han, Jian-Bao, Yu, Dandan, Deng, Zhong-Hua, Qu, Wang, Long, Junyi, Li, Ming-Hua, Yao, Yong-Gang, Zeng, Jianxiong |
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| Zdroj: |
Cell Discovery; 9/30/2022, Vol. 8 Issue 1, p1-5, 5p |
| Abstrakt: |
To evaluate long-term impact of SARS-CoV-2 infection to the brain, the hACE2 transgenic mice as described previously[7] were intranasally infected with a single low dose (1 × 10 SP 2 sp TCID SB 50 sb ) of prototyped SARS-CoV-2 and maintained for up to 30 days post infection (dpi) (Fig. These authors contributed equally: Guanqin Ma, Deng-Feng Zhang, Qing-Cui Zou, Xiaochun Xie Dear Editor, SARS-CoV-2-induced multi-lineage neural cell dysregulation has been documented[1]. Initially, we conducted co-immunoprecipitation (co-IP) in HEK293T cells and found that SARS-CoV-2 Spike S2 subunit (S-S2), but not S-S1 protein, interacted individually with PEN-2 (Fig. SARS-CoV-2 Spike protein S2 subunit modulates -secretase and enhances amyloid- production in COVID-19 neuropathy. [Extracted from the article] |
| Databáze: |
Complementary Index |
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