| Autor: |
S., Niveditha, Vyshak, S., K. V., Giriraja, Jacob, M. J. |
| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2022, Vol. 13 Issue 6, p119-129, 11p |
| Abstrakt: |
Background: The majority of epidemiological studies have shown that vitamin D deficiency is a risk factor for arterial hypertension and cerebrovascular disease. Experimental studies support the notion that vitamin D exerts antihypertensive effects and has a beneficial impact on the overall cerebrovascular risk profile and on stroke outcome. OBJECTIVES: To study the incidence of Vitamin-D deficiency in patients with cerebrovascular disease. To study if Vitamin-D deficiency is an independent risk factor for ischemic stroke. Material & Methods: Study Design: Hospital based observational study. Study area: M V J Medical College and Research Hospital, Hosakote, Bengaluru. Study Period: August 2021 to Feb. 2022. Study population: Patients of ischaemic cerebrovascular stroke attending the OP/ER were included in the study. Sample size: Study consisted a total of 50 cases. The VIDAS® 25-OH Vitamin D Total Assay exhibits excellent analytical data which makes it suitable for use in a clinical setting. The Measuring range is broad (8.1-126 ng/mL) with excellent linearity. It has excellent correlation with Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS). It is the most relevant clinical indicator for the determination and monitoring of vitamin D nutritional status. Results: Correlation between NIHSS score and Vit-D was moderately negative (r=-0.697) and it was highly statistically significant. So, the NIHSS score and Vit-D levels were inversely related. Correlation between orpington score and Vit-D was moderately negative (r=-0.66) and it was highly statistically significant. So, the Orpington score and Vit-D levels were inversely related. CONCLUSION: In addition to the already known risk factors, Vit-D deficiency can be considered as a modifiable emerging risk factor for Cerebrovascular stroke, though further studies are required to prove this. Understanding is important because it may provide the rationale to use vitamin D supplementation to reduce stroke risk in some patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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