| Autor: |
Luscieti, P., Graff, P., Luethi, M., Cottier, H., Hess, M. W., Kraft, R., Stoner, R. D. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; May1983, Vol. 52 Issue 2, p455-462, 8p |
| Abstrakt: |
We have studied cellular kinetic changes in the thymic cortex of ageing mice as a function of time after primary and secondary stimulation with aluminum phosphate adsorbed tetanus toxoid via the hind leg footpads. Absolute numbers of DNA synthesizing cortical thymocytes per cross-section of the thymus were computed from combined data obtained by planimetry, counts of cell density (cellularity) and assessment of the labelling index, I h after injection of (methyl--³H)-thymidine. The proliferative activity of these cells in the outer fourth of the thymic cortex reached a peak exceeding significantly control values by 45%, 14 days after primary, but not secondary, peripheral antigenic stimulation. We conclude that the cortical thymocyte population responded in a distinct manner to the first immunization as opposed to the booster injection of the same antigen. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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