| Autor: |
Bolotin, Shelly, Osman, Selma, Hughes, Stephanie L, Ariyarajah, Archchun, Tricco, Andrea C, Khan, Sumaiya, Li, Lennon, Johnson, Caitlin, Friedman, Lindsay, Gul, Nazish, Jardine, Rachel, Faulkner, Maryrose, Hahné, Susan J M, Heffernan, Jane M, Dabbagh, Alya, Rota, Paul A, Severini, Alberto, Jit, Mark, Durrheim, David N, Orenstein, Walter A |
| Předmět: |
|
| Zdroj: |
Journal of Infectious Diseases; Oct2022, Vol. 226 Issue 7, p1127-1139, 13p |
| Abstrakt: |
Background: We conducted a systematic review to assess whether measles humoral immunity wanes in previously infected or vaccinated populations in measles elimination settings.Methods: After screening 16 822 citations, we identified 9 articles from populations exposed to wild-type measles and 16 articles from vaccinated populations that met our inclusion criteria.Results: Using linear regression, we found that geometric mean titers (GMTs) decreased significantly in individuals who received 2 doses of measles-containing vaccine (MCV) by 121.8 mIU/mL (95% confidence interval [CI], -212.4 to -31.1) per year since vaccination over 1 to 5 years, 53.7 mIU/mL (95% CI, -95.3 to -12.2) 5 to 10 years, 33.2 mIU/mL (95% CI, -62.6 to -3.9), 10 to 15 years, and 24.1 mIU/mL (95% CI, -51.5 to 3.3) 15 to 20 years since vaccination. Decreases in GMT over time were not significant after 1 dose of MCV or after infection. Decreases in the proportion of seropositive individuals over time were not significant after 1 or 2 doses of MCV or after infection.Conclusions: Measles antibody waning in vaccinated populations should be considered in planning for measles elimination. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
