| Autor: |
Clavero, Rene, Parra-Lucares, Alfredo, Méndez-Valdés, Gabriel, Villa, Eduardo, Bravo, Karin, Mondaca, Evelyn, Aranda, Josseline, Brignardello, Rose, Gajardo, Cynthia, Ordenes, Angelica, Colombo, Evelyn, Tapia, Jessica, Etcheverry, Andoni, Zúñiga, José, Toro, Luis |
| Předmět: |
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| Zdroj: |
Vaccines; Sep2022, Vol. 10 Issue 9, p1542-N.PAG, 11p |
| Abstrakt: |
The CoronaVac vaccine is the most used anti-SARS-CoV-2 vaccine worldwide. Previous data indicate that this vaccine produces a lower immune response than RNA vaccines such as BNT162b2. End-stage renal disease (ESRD) patients have an increased rate of COVID-19 and a reduced immune response to vaccinations. Currently, there is little data on this population's immune response induced by CoronaVac. Methods: This study involved a prospective cohort of ESRD patients in chronic hemodialysis who received a two-dose immunization scheme of either CoronaVac (Sinovac Biotech) or BNT162b2 vaccines (Pfizer-BioNTech). We measured the plasma levels of anti-SARS-CoV-2 IgG antibodies. We determined antibody titers before immunization, 2 and 4 months after two doses, plus 4 months after a booster dose. Results: We evaluated 208 patients in three hemodialysis centers. The mean age was 62.6 ± 15.6 years, of whom 91 were female (41.75%). Eighty-one patients (38.94%) received the BNT162b2 vaccine and 127 (61.06%) received the CoronaVac vaccine. Patients who received the BNT162b2 vaccine had a higher humoral response compared to those who received the CoronaVac vaccine (4 months after the second dose: BNT162b2: 88.89%, CoronaVac: 51.97%, p < 0.001; 4 months after the booster: BNT162b2: 98.77%, CoronaVac: 86.61%, p < 0.001). Conclusions: Our results suggest that the CoronaVac vaccine induced a lower humoral response than the BNT162b2 vaccine in ESRD patients on hemodialysis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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