Dramatic Recovery after Etoposide Phosphate Infusion for Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome following Treatment with Tisagenlecleucel in a Young Patient with Relapsed Acute Lymphoblastic Leukemia: A Case Report.

Autor:	Peterlin, Pierre, Garnier, Alice, Le Bourgeois, Amandine, Jullien, Maxime, Seguin, Amélie, Eveillard, Marion, Béné, Marie-Christine, Guillaume, Thierry, Chevallier, Patrice
Předmět:	HEMOPHAGOCYTIC lymphohistiocytosis LYMPHOBLASTIC leukemia ACUTE leukemia MACROPHAGE activation syndrome ETOPOSIDE PHOSPHATES
Zdroj:	Acta Haematologica; Sep2022, Vol. 145 Issue 5, p537-541, 5p
Abstrakt:	The occurrence of a secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) after CAR T-cell infusion is very rare and mostly fatal. Treatment recommendations for such a complication are not yet established. Here, we report the dramatic recovery of HLH/MAS following tisagenlecleucel infusion in a young patient with relapsed acute lymphoblastic leukemia using etoposide phosphate (EP). We propose that monitoring for the occurrence of HLH/MAS should be part of surveillance after CAR T-cell infusion and that EP treatment appears to be useful to control this severe and rare complication. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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