| Autor: |
Jones, Charlotte H., Gui, Wei, Schumann, Ricarda G., Boneva, Stefaniya K., Lange, Clemens A. K., van Overdam, Koen A., Chui, Toco Y. P., Rosen, Richard B., Engelbert, Michael, Sebag, J. |
| Předmět: |
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| Zdroj: |
Expert Review of Ophthalmology; Aug2022, Vol. 17 Issue 4, p263-280, 18p |
| Abstrakt: |
Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes. Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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