| Autor: |
ROUKAS, DIMITRIOS, KOUZOUPIS, ANASTASIOS, SPYROPOULOU, DESPOINA, PAPANASTASIOU, GEORGE, TSIAMBAS, EVANGELOS, TSOUVELAS, GEORGE, FALIDAS, EVANGELOS, RAGOS, VASILEIOS, PESCHOS, DIMITRIOS, MANAIOS, LOUKAS, KATSINIS, SPYROS, MANOLI, AREZINA, PAPOULIAKOS, SOTIRIOS, LAZARIS, ANDREAS C., KAVANTZAS, NIKOLAOS |
| Předmět: |
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| Zdroj: |
In Vivo; Sep/Oct2022, Vol. 36 Issue 5, p2205-2210, 6p |
| Abstrakt: |
Background/Aim: Meningiomas represent the main intracranial primary central nervous system (CNS) tumour in adults worldwide. Oncogenes' over-activation combined with suppressor genes' silencing affect negatively the biological behavior of these neoplasms. This study aimed to explore the impact of p53 suppressor gene expression in meningiomas' clinic-pathological features based on a combination of sophisticated techniques. Materials and Methods: Fifty (n=50) meningiomas were included in the study, comprising a broad spectrum of histopathological subtypes. An immunohistochemistry assay was applied on tissue microarray cores followed by digital image analysis. Results: p53 protein over-expression (high staining intensity levels) was observed in 27/50 (54%) cases, whereas the rest (23/50-/46%) demonstrated moderate to low levels of the protein. p53 over-expression was statistically significantly correlated to the mitotic index of the examined cases (p-value=0.001). Interestingly, the atypical/anaplastic group of histotypes demonstrated the strongest p53 expression rates compared to the others (p-value=0.001). Conclusion: p53 overexpression is observed in a broad spectrum of meningiomas. High expression levels lead to an aggressive biological behavior of the malignancy (combined with increased mitotic rates), especially in atypical and anaplastic sub-types that also have a high recurrence rate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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