| Autor: |
Venetianer, A., Arányi, P., Bösze, ZS., Fachet, J. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Oct1978, Vol. 8 Issue 4, p355-362, 8p |
| Abstrakt: |
Sensitization of B10,A mice with oxazolone results in delayed-type hypersensitivity (DTH) and a two- to three-fold increase in the weight of regional lymph nodes by the third day. Hydrocortisone treatment of the animals 3 days, after sensitization suppresses the manifestation of DTH on the tenth day but not on the seventieth day and significantly decreases the weight of lymph nodes both in control and oxazolone-sensitized mice. The regional lymph node cells of oxazolone-stimulated mice were, like the controls, sensitive to dexamethasone in vitro, as judged by viability and thymidine incorporation. Dexamethasone binding capacity of the regional lymph node cells 75 h after oxazolone sensitization increased. However, the dissociation constant for dexamethasone, the binding specificity, and the nuclear transfer of the hormone were not altered. Since high doses of hydrocortisone given 3 days after sensitization were unable to erase permanently the DTH to oxazolone, it seems very likely that cells responsible for the immunological memory survive the high dose of hydrocortisone. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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