| Autor: |
Sun, Yi-Qian, Girgensone, Ilze, Leanderson, Per, Petersson, Fredrik, Borch, Kurt |
| Předmět: |
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| Zdroj: |
Helicobacter; Feb2005, Vol. 10 Issue 1, p33-42, 10p |
| Abstrakt: |
Epidemiological studies show that high intake of food-bound vitamin C and E reduces the risk of gastric cancer. Whether dietary supplementation with antioxidant micronutrients interferes withHelicobacter pyloriinfection and associated diseases is unclear. The aim of this study was to investigate if dietary vitamin C or E supplementation influences the progression of gastritis, gastric mucosal nitrosative and oxidative protein damage, gastric mucosal lipid peroxidation, or gastric mucosal oxidative DNA damage inH. pylori-infected Mongolian gerbils.Gerbils were divided into four groups:H. pylori-infected animals fed with vitamin C- or vitamin E-supplemented food, and infected and uninfected animals given standard rodent food. Subgroups of animals were killed at different time-points until 52 weeks postinfection. Concentrations of 3-nitrotyrosine and thiobarbituric acid-reactive substances (TBARS) in the gastric mucosa were determined with an immunodot blot and a fluorometric method, respectively. Mucosal concentrations of carbonyl carbons on proteins and 8-hydroxydeoxyguanosine were determined by enzyme-linked immunosorbent assay. Gastritis was scored semiquantitatively.Vitamin supplements had no effect on the colonization withH. pylori. Vitamin C as well as vitamin E supplements reduced mucosal 3-nitrotyrosine concentrations to normal levels in infected animals. Vitamin E supplements decreased mucosal protein carbonyls and TBARS in short-term gastritis. In addition, vitamin C supplements caused attenuated mucosal oxidative DNA damage and milder mucosal inflammation in short-term gastritis.Vitamin C or vitamin E supplementation leads to some short-term protective effects onH. pylori-induced gastritis in Mongolian gerbils. These effects seem to subside over time when the infection persists. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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