| Autor: |
Ferolla, F Martin, Yfran, E Walter, Ballerini, M Gabriela, Caratozzolo, Ana, Toledano, Analía, Giordano, Ana C, Acosta, Patricio L, Cassinelli, Hamilton, Bergada, Ignacio, Ropelato, M Gabriela, Contrini, María M, López, Eduardo L, Network, GUTI Respiratory Infections, GUTI Respiratory Infections Network |
| Předmět: |
|
| Zdroj: |
Journal of Infectious Diseases; 9/15/2022, Vol. 226 Issue 6, p958-966, 9p |
| Abstrakt: |
Background: 25-hydroxyvitamin D (VD) effects on lung function and immune-modulation might affect respiratory syncytial virus (RSV) infection outcomes. We aimed to assess VD levels on admission and their association with life-threatening RSV disease (LTD).Methods: A prospective cohort study was conducted during 2017-2019. Previously healthy infants aged <12 months, hospitalized with a first episode of RSV infection, were enrolled. LTD was defined by need for intensive care and ventilatory support. Serum VD levels <20 ng/mL were categorized as deficient, and 20-29.9 ng/mL as insufficient.Results: Of 125 patients studied, 73 (58%) were male. Median age was 4 months. Twenty-two patients developed LTD. No differences in viral load were seen between cases with LTD and controls (P = .94). Patients who developed LTD had significantly lower VD levels: median 18.4 ng/mL (IQR, 15.1-26.9 ng/mL) versus 31.7 ng/mL (IQR, 23.6-42.0 ng/mL), P < .001; 59% of infants with LTD had VD deficiency compared with 12% in those with better outcome. Multivariable regression analysis confirmed VD deficiency as a risk factor (odds ratio, 11.83; 95% confidence interval, 3.89-35.9; P < .001).Conclusions: These findings provide additional evidence for the development of strategies to prevent severe RSV infections. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
