Cancer survivorship care for young adults: a risk-stratified, multicenter randomized controlled trial to improve symptoms.

Autor: Syrjala, Karen L., Walsh, Casey A., Yi, Jean C., Leisenring, Wendy M., Rajotte, Emily Jo, Voutsinas, Jenna, Ganz, Patricia A., Jacobs, Linda A., Palmer, Steven C., Partridge, Ann, Baker, K. Scott
Zdroj: Journal of Cancer Survivorship; Oct2022, Vol. 16 Issue 5, p1149-1164, 16p
Abstrakt: Purpose: Young adult (YA) cancer survivors have high rates of adverse health and psychosocial outcomes. This risk-stratified, multicenter, randomized controlled trial (RCT) compared a self-management survivorship intervention to usual care in YA survivors with symptoms of cancer-related distress, insomnia, fatigue, pain, and/or depression.Methods: Eligibility included age 18-39 at diagnosis with an invasive malignancy in the previous 1-5 years. Baseline assessment determined "high need" participants, with 2-5 elevated targeted symptoms. We randomized high need participants to intervention or usual care and offered intervention participants a survivorship clinic visit, which included mutually decided action plans for symptoms. Follow-up calls at 1 and 3 months after the clinic visit reviewed action plan progress. Outcomes compared rates of improved symptoms for intervention vs usual care at 6 months and 12 months.Results: N = 344 completed baseline assessment, with n = 147 (43%) categorized as high need and randomized. Of n = 73 randomized to the intervention, n = 42 (58%) did not attend their survivorship clinic visit. In intent-to-treat analyses, aggregate symptom scores did not differ between arms, though distress improved for 46% in the intervention arm at 6 months compared to 18% in usual care (p = 0.03) among those with elevated distress at baseline.Conclusions: Distress improved for YAs who received self-management survivorship care. However, the study demonstrates a need for alternative strategies for providing YA survivorship care.Trial Registration: NCT02192333 IMPLICATIONS FOR CANCER SURVIVORS: While YA survivors demonstrate some improved distress when provided survivorship care, to make care accessible and effective, they require options such as remote delivery of care. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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