Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort.

Autor:	Ronaldson, Amy, Arias de la Torre, Jorge, Gaughran, Fiona, Bakolis, Ioannis, Hatch, Stephani L., Hotopf, Matthew, Dregan, Alexandru
Předmět:	MENTAL depression risk factors TISSUE banks SCIENTIFIC observation HUMAN research subjects CONFIDENCE intervals VITAMIN D INFORMED consent (Medical law) MATHEMATICAL variables MENTAL depression QUESTIONNAIRES DESCRIPTIVE statistics SOCIODEMOGRAPHIC factors VITAMIN D deficiency LOGISTIC regression analysis DATA analysis software ODDS ratio LONGITUDINAL method MIDDLE age
Zdroj:	Psychological Medicine; Jul2022, Vol. 52 Issue 10, p1866-1874, 9p
Abstrakt:	Background: A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle-aged adults enrolled in the UK Biobank. Methods: We assessed prospective associations between vitamin D status at the baseline assessment (2006–2010) and depression measured at the follow-up assessment (2016) in 139 128 adults registered with the UK Biobank. Results: Amongst participants with no depression at baseline (n = 127 244), logistic regression revealed that those with vitamin D insufficiency [adjusted odds ratio (aOR) = 1.14, 95% confidence interval (CI) = 1.07–1.22] and those with vitamin D deficiency (aOR = 1.24, 95% CI 1.13–1.36) were more likely to develop new-onset depression at follow-up compared with those with optimal vitamin D levels after adjustment for a wide range of relevant covariates. Similar prospective associations were reported for those with depression at baseline (n = 11 884) (insufficiency: aOR = 1.11, 95% CI 1.00–1.23; deficiency: aOR = 1.30, 95% CI 1.13–1.50). Conclusions: The prospective associations found between vitamin D status and depression suggest that both vitamin D deficiency and insufficiency might be risk factors for the development of new-onset depression in middle-aged adults. Moreover, vitamin D deficiency (and to a lesser extent insufficiency) might be a predictor of sustained depressive symptoms in those who are already depressed. Vitamin D deficiency and insufficiency is very common, meaning that these findings have significant implications for public health. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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