| Autor: |
Ceglarek, Bernadeta, Górska-Kosicka, Magda, Gwozdowska, Adela, Sikorska, Anna, Windyga, Jerzy |
| Předmět: |
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| Zdroj: |
Acta Haematologica Polonica; 2022, Vol. 53 Issue A, p85-85, 1/2p |
| Abstrakt: |
Introduction: Primary immune thrombocytopenia (ITP) isan acquired bleeding diathesis in which therapy isnecessary in symptomatic patientsor in case of very low platelet counts (<30.0 G/L). Treatmentof chronic symptomatic ITP, not responding to corticosteroids and intravenous immunoglobulins (IVIg) or dependent on corticosteroids or IVIg use can be very difficult. The second line therapies include rituximab, thrombopoietin receptor agonists (TPO-RA) and splenectomy, yet these therapies are also often ineffective. Dapsone, whichis an antibacterial sulfonamide with antiinflammatory property has therapeutic activity in patients with ITP. Objective: To evaluate the efficacy and safety of dapsone in ITP patients who relapsed after splenectomy. Material and methods: The study comprised 7 subjects (5 females, 2 males, aged 48-72 years) with chronic ITP who failed first line therapy and relapsed after splenectomy, and, in whom G6PD deficiency was ruled out. None of the patient has received TPO-RA. Median platelet count before dapsone therapy was 1.0-8.0 G/L The range interval between diagnosis of ITP and dapsone comencement was 2-46 years. Dapsone dose was 50-100 mg daily in association with either steroids (7 patients) or IVIg (6 patients). Results: Duration of dapsone therapy was 33 days to 87 months. The post-dapsone platelet counts were 19.0-101.0 G/L, after a minimum of 38 days. Bleeding diathesis has improved in 6/7 patients. Side effects included diarrhoea, urinary and respiratory tract infections, and were observed in 4/7 patients. At present 2 female patients still receive dapsone (12.5-100 mg/d) and intermittently a low-dose prednisone. The therapy is well tolerated and platelet count maintained between 31.0 and 81.0 G/L. Conclusions: Dapsone is a viable treatment option in selected patients with chronic ITP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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