| Autor: |
Bembnista, Ewa, Łuszczyńska, Patrycja, Matuszak, Paula, Majewska, Ewa, Kaźmierska, Katarzyna, Łojko-Dankowska, Anna, Dytfeld, Dominik, Matuszak, Magdalena, Wache, Anna, Lewandowski, Krzysztof, Gil, Lidia |
| Předmět: |
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| Zdroj: |
Acta Haematologica Polonica; 2022, Vol. 53 Issue A, p73-74, 2p |
| Abstrakt: |
The SARS-CoV-2 pandemic has caused the need to change the global standards for allogeneic hematopoietic cell processing for transplantation by routinely cryopreserving the transplant material. We analyzed the results of hematopoiesis reconstitution in a group of 50 patients who underwent transplantation with cryopreserved cellular material (group A) and in a group of 50 patients who underwent transplantation with non-cryopreserved cellular material (group B). The analysis included patients treated due to acute myeloid leukemia (AML) in the Department of Hematology and Bone Marrow Transplantation, Poznań University of Medical Sciences. Statistical evaluation of neutrophil recovery indicates a required time of 19 for group A and 18 days in group B. The statistical analysis also show that tere were no statistically significant differences in the analyzed parameter (p = = 0.8563). The median white blond cell (WBC) reconstitution time in patients was 17 days in both groups. There were no statistical differences between groups (p = 0.8628). The time required to platelet engraftment (PLT >20 × × 109/L) was also evaluated. In both groups, the median number of days to restore platelet count was 14 days. Analysis showed that tere were no significant statistical differences between the groups (p = 0.8920). The time for patients to reach reference values of neutrophil and WBC was evaluated. The median time to reach the neutophil reference value was 22 and 21 days in group A and B, respectively. In contrast, the median time to reach the WBC reference value was 25 and 23 of in groups A and B, respectively. There were no statistically significant difference between the two groups in the parameters analyzed (p = 0.3895 for neutrophil; p = 0.3513 for WBC). In conclusion, transplantation of patients diagnosed with AML using cryopreserved cellular material does not affect the clinical parameters of hematopoietic recovery time of patients treated with transplantation. Cryopreservation of allogenic haematopoietic stem cell product, haematopoietics reconstitution recovery, processing of cells for transplantation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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