Pilot study for immunoglobulin E as a prognostic biomarker in coronavirus disease 2019.

Autor:	Aydin Guclu, Ozge, Goktas, Seda S., Gorek Dilektasli, Asli, Acet Ozturk, Nilufer A., Demirdogen, Ezgi, Coskun, Funda, Ediger, Dane, Ursavas, Ahmet, Uzaslan, Esra, Erol, Hasim A., Karacay, Nurdan D., Kaya Sel, Umut, Karadag, Mehmet
Předmět:	DISEASE progression BIOMARKERS PILOT projects EOSINOPHILS REFERENCE values C-reactive protein COVID-19 IMMUNOGLOBULINS PREDICTIVE tests MULTIVARIATE analysis RISK assessment SEVERITY of illness index HOSPITAL care DESCRIPTIVE statistics SENSITIVITY & specificity (Statistics) RECEIVER operating characteristic curves HEALTH care rationing
Zdroj:	Internal Medicine Journal; Sep2022, Vol. 52 Issue 9, p1495-1504, 10p
Abstrakt:	Background: Laboratory biomarkers to estimate the severity of coronavirus disease 2019 (COVID‐19) are crucial during the pandemic since resource allocation must be carefully planned. Aims: To evaluate the effects of basal serum total immunoglobulin E (IgE) levels and changes in inflammatory parameters on the clinical progression of patients hospitalised with COVID‐19. Methods: Patients hospitalised with confirmed COVID‐19 were included in the study. Laboratory data and total IgE levels were measured on admission. Lymphocyte, eosinophil, ferritin, d‐dimer and C‐reactive protein parameters were recorded at baseline and on the 3rd and 14th days of hospitalisation. Results: The study enrolled 202 patients, of which 102 (50.5%) were males. The average age was 50.17 ± 19.68 years. Of the COVID‐19 patients, 41 (20.3%) showed clinical progression. Serum total IgE concentrations were markedly higher (172.90 (0–2124) vs 38.70 (0–912); P < 0.001) and serum eosinophil levels were significantly lower (0.015 (0–1.200) vs 0.040 (0–1.360); P = 0.002) in clinically worsened COVID‐19 patients when compared with stable patients. The optimal cut‐off for predicting clinical worsening was 105.2 ng/L, with 61% sensitivity, 82% specificity, 46.3% positive predictive value and 89.2% negative predictive value (area under the curve = 0.729). Multivariable analysis to define risk factors for disease progression identified higher total IgE and C‐reactive protein levels as independent predictors. Conclusions: Our single‐centre pilot study determined that total IgE levels may be a negative prognostic factor for clinical progression in patients hospitalised due to COVID‐19 infection. Future studies are required to determine the impact of individuals' underlying immune predispositions on outcomes of COVID‐19 infections. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text