Synthesis, Biological Evaluation and Molecular Docking of Novel N-Acyl/Aroyl Spiro[Chromane-2,4′-Piperidin]-4(3H)-One as Potent Anti-Microbial Agents.

Autor:	Ghatpande, Nitin, Phal, Deepak, Karpoormath, Rajshekhar, Soliman, Mahmoud, Jadhav, Jagannath, Choudhari, Prafulla, Shaikh, Mahidansha M.
Předmět:	MOLECULAR docking ANTI-infective agents CHEMICAL synthesis AMIDATION ACETOPHENONE
Zdroj:	Polycyclic Aromatic Compounds; 2022, Vol. 42 Issue 8, p4878-4894, 17p
Abstrakt:	An efficient and convenient method for the synthesis of a novel N-acyl/aroyl spiro[chromane-2,4′-piperidin]-4(3H)-one analogue was developed via two stage condensation of α-hydroxy acetophenone with 4-pipyridinone followed by amidation reaction with various acids in presence of amide coupling agent. These newly synthesized compounds exhibited excellent docking integrations with MDS 4.6 as well as good anti-fungal and anti-microbial activities. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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