| Autor: |
Aasted, B., Bernstein, D., Klapper, D. G., Kholy, A. El, Krause, R. M. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Immunology; Jan1979, Vol. 9 Issue 1, p61-67, 7p |
| Abstrakt: |
Human antibodies to streptococcal groups A and C carbohydrates were measured quantitatively with a radioimmunoassay using tyrosylated 125I carbohydrate. Analysis of acute and convalescent sera from people with groups A or C streplococcal pharyngeal infection or persistent carriage revealed a significant rise in antibodies. Inhibition reactions with the cold carbohydrate indicated the specificity of the elicited antibodies, in some instances, group C as well as group A antibodies occurred after group A pharyngeal infections. Further clinical and epidemiological studies are required to determine the significance of group-specific antibodies. Antistreptolysin-O (ASO) rises were observed in individuals with group C antibody responses after persistent group C pharyngeal carriage. For this reason, epidemiological surveys that rely primarily on ASO surveys to determine the incidence of group A streplococcal infections must be interpreted with caution, at least in the developing countries, where group C pharyngeal carriage is common. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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