| Autor: |
Zharkikh, E. V., Loktionova, Yu. I., Sidorov, V. V., Krupatkin, A. I., Masalygina, G. I., Dunaev, A. V. |
| Předmět: |
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| Zdroj: |
Human Physiology; Aug2022, Vol. 48 Issue 4, p456-464, 9p |
| Abstrakt: |
In this study, we assessed the possibility of using portable laser Doppler flowmeters for determining the state of the blood microcirculatory system in upper and lower limbs of diabetic patients during the treatment course with intravenous α-lipoic acid infusions. A series of experimental studies were conducted in a cohort of ten inpatients with a confirmed diagnosis of type 2 diabetes mellitus. The state of peripheral blood flow of patients was assessed during 5 days on which they received daily doses of intravenous α-lipoic acid infusions. The values of the microcirculation and nutritive blood flow indices, as well as the bypass index, were assessed. To obtain a more extensive analysis, the patients' measurement results were compared with those of the control group composed of ten conditionally healthy volunteers of similar age. To determine changes in the regulatory mechanisms for the microcirculatory bed, we applied the amplitude-spectrum analysis of microvascular blood flow oscillations, using the mathematical tool of wavelet transform. We determined the changes in the index of blood microcirculation and the parameters of microcirculatory blood flow distribution into nutritive and shunt pathways, as well as the differences between these changes in upper and lower limbs. This approach is believed to become prospective as a pharmacotherapy efficacy assessment method based on responses of the system of blood microcirculation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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