An optimized mouse model of Staphylococcus aureus infected diabetic ulcers.

Autor:	MENDES, Ana Isabel, PEIXOTO, Maria João, MARQUES, Alexandra Pinto, PEDROSA, Jorge, FRAGA, Alexandra Gabriel
Předmět:	STAPHYLOCOCCUS aureus LABORATORY mice ANIMAL disease models METHICILLIN-resistant staphylococcus aureus DIABETIC foot WOUND healing
Zdroj:	BMC Research Notes; 9/7/2022, Vol. 15 Issue 1, p1-6, 6p
Abstrakt:	Objective: Diabetic foot infection (DFI) represents a major healthcare burden, for which treatment is challenging owing to the pathophysiological alterations intrinsic to diabetes and the alarming increase of antimicrobial resistance. Novel therapies targeting DFI are therefore a pressing research need for which proper models of disease are required. Results: Here, we present an optimized diabetic mouse model of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, that resemble key features of DFI, such as pathogen invasion through wound bed and surrounding tissue, necrosis, persistent inflammation and impaired wound healing. Thus, in a time-efficient manner and using simple techniques, this model represents a suitable approach for studying emerging therapies targeting DFI caused by MRSA. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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